SYSTEMIC IMMUNE MODULATION ALTERS LOCAL BONE REGENERATION IN A DELAYED TREATMENT COMPOSITE MODEL OF NON-UNION EXTREMITY TRAUMA

Systemic Immune Modulation Alters Local Bone Regeneration in a Delayed Treatment Composite Model of Non-Union Extremity Trauma

Bone non-unions resulting from severe traumatic injuries pose significant clinical challenges, and the biological factors that drive progression towards and healing from these injuries are still not well understood.Recently, a dysregulated systemic immune response following musculoskeletal trauma has been identified as a contributing factor for poo

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Systemic down-regulation of delta-9 desaturase promotes muscle oxidative metabolism and accelerates muscle function recovery following nerve injury.

The progressive deterioration of the neuromuscular axis is typically observed in degenerative conditions of the lower motor neurons, such as amyotrophic lateral sclerosis (ALS).Neurodegeneration in this disease is associated with systemic metabolic perturbations, including hypermetabolism Game Controllers and dyslipidemia.Our previous gene profilin

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